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Related Concept Videos

Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
Cancer Cell Migration through Invadopodia01:35

Cancer Cell Migration through Invadopodia

Invadosome is a broad category of cell surface structures with proteolytic activity that  degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However, invadopodia can...

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Related Experiment Video

Updated: Jul 7, 2026

Injection of Syngeneic Murine Melanoma Cells to Determine Their Metastatic Potential in the Lungs
07:31

Injection of Syngeneic Murine Melanoma Cells to Determine Their Metastatic Potential in the Lungs

Published on: May 24, 2016

Metastatic cancer cell.

Marina Bacac1, Ivan Stamenkovic

  • 1Experimental Pathology Unit, Department of Pathology, University of Lausanne, Switzerland. Marina.Bacac@chuv.ch

Annual Review of Pathology
|February 1, 2008
PubMed
Summary

Cancer cell metastasis involves adapting to and subverting distant tissue microenvironments. Advances reveal the host tissue stroma

Area of Science:

  • Oncology
  • Cancer Biology
  • Cellular Microenvironment

Background:

  • Metastasis is a complex process where cancer cells spread from a primary tumor to distant sites.
  • Successful metastasis requires cancer cells to adapt to and manipulate foreign tissue microenvironments for survival and proliferation.

Purpose of the Study:

  • To explore the role of the host tissue stroma in promoting tumor cell growth and dissemination.
  • To gain insight into the genetic factors driving cancers with high metastatic potential.

Main Methods:

  • Review of recent conceptual advances in understanding cancer metastasis.
  • Analysis of technological advancements in studying the tumor microenvironment.
  • Examination of genetic data from high-metastatic-proclivity cancers.

More Related Videos

Tracking Tumor Cell Dissemination from Lung Metastases Using Photoconversion
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Tracking Tumor Cell Dissemination from Lung Metastases Using Photoconversion

Published on: July 7, 2023

Experimental Metastasis Assay
08:28

Experimental Metastasis Assay

Published on: August 24, 2010

Related Experiment Videos

Last Updated: Jul 7, 2026

Injection of Syngeneic Murine Melanoma Cells to Determine Their Metastatic Potential in the Lungs
07:31

Injection of Syngeneic Murine Melanoma Cells to Determine Their Metastatic Potential in the Lungs

Published on: May 24, 2016

Tracking Tumor Cell Dissemination from Lung Metastases Using Photoconversion
05:23

Tracking Tumor Cell Dissemination from Lung Metastases Using Photoconversion

Published on: July 7, 2023

Experimental Metastasis Assay
08:28

Experimental Metastasis Assay

Published on: August 24, 2010

Main Results:

  • The host tissue stroma plays a critical role in facilitating tumor cell growth and spread.
  • Understanding cancer cell adaptation to foreign microenvironments is key to metastasis.
  • Genetic makeup significantly influences a cancer's propensity for metastasis.

Conclusions:

  • Host tissue stroma actively promotes cancer cell dissemination and survival.
  • Further research into the genetic basis of metastasis can identify therapeutic targets.
  • Targeting microenvironmental interactions may offer new strategies against metastatic cancer.