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Susceptibility to active decompensated cirrhosis is associated with polymorphisms of intercellular adhesion

X Q Zhang1, X J Hong, X J Bai

  • 1Department of Infectious Diseases, Southwest Hospital, Chongqing, People's Republic of China. zuqing651005@tom.com

Journal of Viral Hepatitis
|February 1, 2008
PubMed

Insights

Specific Intercellular adhesion molecule-1 (ICAM-1) gene variations are linked to hepatitis B virus (HBV) infection outcomes. The R241-E469 haplotype increases susceptibility to active decompensated cirrhosis in HBV carriers.

Area of Science:

  • Immunogenetics
  • Hepatology
  • Viral Hepatitis Research

Background:

  • Intercellular adhesion molecule-1 (ICAM-1) is implicated in the pathogenesis of hepatitis B.
  • Genetic variations (polymorphisms) in the ICAM-1 gene are associated with inflammatory diseases.
  • Understanding ICAM-1 polymorphisms may reveal insights into chronic hepatitis B progression.

Purpose of the Study:

  • To investigate the association between ICAM-1 polymorphisms at codons G241R and K469E and the risk of developing active decompensated cirrhosis in chronic hepatitis B virus (HBV) carriers.
  • To analyze the frequencies of specific ICAM-1 genotypes and haplotypes in different stages of chronic HBV infection.

Main Methods:

  • Sequence-specific primer polymerase chain reaction (PCR-SSP) was used to genotype ICAM-1 polymorphisms (G241R and K469E).
  • The study included 572 chronic HBV carriers and 157 healthy, HBV-negative controls.
  • Genotype and haplotype frequencies were compared across patient groups: active decompensated cirrhosis, chronic hepatitis B (CHB), and asymptomatic HBV carriers (AsC).

Main Results:

  • Significantly higher frequencies of the R allele at codon 241 and the E allele at codon 469 were observed in patients with active decompensated cirrhosis compared to CHB and AsC groups.
  • The R241-E469 haplotype and genotypes containing this haplotype were more prevalent in patients with active decompensated cirrhosis than in CHB patients, and in CHB patients compared to AsC.
  • A dose-dependent increase in disease susceptibility was noted with the presence of the R241-E469 haplotype.

Conclusions:

  • ICAM-1 polymorphisms at codons G241R and K469E are associated with disease susceptibility in chronic HBV infection.
  • Carrying at least one R241-E469 haplotype significantly increases the risk of developing active decompensated cirrhosis in chronic HBV carriers.

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