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Updated: Jul 7, 2026
Murine Intrapulmonary Tracheal Transplantation: A Model for Investigating Obliterative Airway Disease After Lung Transplantation
Published on: November 10, 2023
Influence of cyclosporine A on mucociliary system after lung transplantation in rats
Alexandre Martins Xavier1, Paulo Manuel Pêgo-Fernandes, Aristides Tadeu Correia
1Thoracic Surgery Division, Department of Surgery, Federal University of São Paulo (UNIFESP)São Paulo, Brazil.
Purpose:
To investigate the function of the bronchial mucociliary system in transplanted rat lungs with and without the influence of immunosuppression.
Methods:
Thirty-six rats underwent single-lung transplantation and were divided into two groups, one of which received cyclosporine treatment, and the control group which did not. Cyclosporine was administered subcutaneously in doses of 10 mg/kg daily. The rats were sacrificed 2, 15 or 30 days after transplantation. In situ bronchial mucociliary transport (MCT) and ciliary beat frequency (CBF) were determined proximal and distal to the bronchial anastomosis.
Results:
Significant progressive improvement on MCT, proximal and distal to the anastomotic site, was also found in the cyclosporine-treated group at 15 and 30 days (p<0.01). No significant change in MCT was found in the control group. CBF behavior in the two groups. Histological analysis showed that rejection was significantly higher in the control group (p<0.05).
Conclusion:
Cyclosporine has a positive influence on bronchial mucociliary transport but not on CBF due to the effect of the rejection mechanism.
