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Related Experiment Video

Updated: Jul 7, 2026

A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression and Evaluate Novel Perioperative Immunotherapies
13:37

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Published on: March 12, 2014

[Surgical trauma and postoperative immunosuppression].

P Koerner1, A Westerholt, W Kessler

  • 1Klinik und Poliklinik für Chirurgie, Abteilung für Allgemein-, Viszeral-, Thorax- und Gefässchirurgie, Universitätsklinikum Greifswald, Greifswald, Germany.

Der Chirurg; Zeitschrift Fur Alle Gebiete Der Operativen Medizen
|February 1, 2008
PubMed
Summary

Abdominal surgery can cause immune dysfunction, increasing mortality risk from sepsis. A new mouse model allows studying this postoperative immune dysfunction and its link to surgical trauma.

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Area of Science:

  • Immunology
  • Surgical Pathology
  • Critical Care Medicine

Context:

  • Abdominal surgery frequently leads to temporary immune dysfunction, increasing sepsis mortality risk.
  • Sepsis acquired postoperatively (Type B) differs immunologically from spontaneously acquired sepsis (Type A).
  • Postoperative immune dysfunction is characterized by reduced HLA-DR on monocytes and increased T-lymphocyte apoptosis.

Purpose:

  • To introduce and validate an adequate animal model for studying surgically induced immune dysfunction.
  • To establish a preclinical model for investigating the mechanisms and consequences of postoperative immune dysfunction.

Summary:

  • Abdominal surgery induces immune dysfunction, correlating with surgical complexity.
  • This dysfunction involves reduced monocyte HLA-DR expression and increased T-cell apoptosis.
  • Intestinal manipulation in mice effectively models surgically induced immune dysfunction.

Impact:

  • Enables novel research into preventing and treating postoperative sepsis.
  • Provides a platform for testing immunomodulatory therapies in surgical patients.
  • Advances understanding of the link between surgical trauma and immune suppression.