Related Experiment Video
Updated: Jul 7, 2026
Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits (Oryctolagus cuniculus)
Published on: July 31, 2021
[Pharmacokinetics of pueraria for intranasal on spray in rabbits]
Yi Lu1, Tong Zhang, Jian-sheng Tao
1Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Objective:
To explore pharmacokinetic features of puerarin in pueraria spray and calculate pharmacokinetic parameters according to puerarin of drug-time curve in rabbits.
Methods:
The concentration of puerarin in plamsa was determined by HPLC. The methanol was used to sediment protine. The 3P87 program was used to calculate the pharmacokinetic parameters.
Results:
The vivo course of pueraria in spray could be described by the two compartment model. The main pharmacokinetic parameters of Pueraria spray were: t(l/2(beta)) =0.93 h, CL =44.23 mg x L(-1), AUC = 16.28 mg x h x L(-1), Cmax =5.9 mg x L(-1) and tmax = 0.975 h.
Conclusion:
The study will provide some scientific basises for the quality evaluation and pharmaceutics reformation of pueraria for intranasal.
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