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Updated: Jul 7, 2026
A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
Published on: September 30, 2021
[Surveillance for hepatocellular carcinoma: does it work?]
Asma Kchaou-Ouakaa1, Najet Belhadjbrik, Hela Elloumi
1Service de gastro-entérologie de l'hôpital Habib Thameur, Tunis, Tunisie.
Background:
The surveillance of cirrhotic patients for early detection of hepatocellular carcinoma is recommended but its efficacy is now discussed. The aim of our study was to present the results of a screening program in 110 patients.
Methods:
it is a retrospective study that included 110 patients with cirrhosis in a screening program of hepatocellular carcinoma, based on the realization of abdominal ultrasound exam and the determination of alpha-fetoprotein amount every 6 months in 95 patients and every 3 months in 15 patients.
Results:
the mean duration of the surveillance was 36 months. A hepatocellular carcinoma was diagnosed in 13 patients. Curative treatment was done in only 3 cases and consisted in a hepatic resection in 1 patient and an alcoolisation in 2 cases. Ten patients had new treatment : for 8 patients the discussed was very agressive and 2 patients had a server hepotic failure. The cost of this study was 37.500 Tunisian dinars.
Conclusions:
systematic screening for hepatocellular carcinoma offer a limited cost effectiveness ratio.
