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[Fibrinolytic therapy in non-coronary diseases]
J C Nicolau1, D M Braile, J D de Araújo
1Instituto de Moléstias Cardiovasculares, São José do Rio Preto, SP.
Arquivos Brasileiros De Cardiologia
|June 1, 1991
Summary
Fibrinolytic drugs effectively treat non-coronary conditions like pulmonary embolism and arterial thrombosis. These treatments offer excellent outcomes, potentially avoiding emergency surgery.
Area of Science:
- Cardiology
- Vascular Medicine
- Pharmacology
Background:
- Fibrinolytic drug use in non-coronary diseases is historically documented but infrequently studied.
- Limited literature exists on the application of these agents beyond acute coronary syndromes.
Observation:
- Three patient cases involving pulmonary embolism, peripheral arterial embolism, and mechanical aortic prosthesis thrombosis were treated with fibrinolytic drugs.
- Clinical presentations varied, sometimes with unexpected symptoms.
- Diagnostic and monitoring tests were crucial for timely treatment decisions, including infusion cessation.
Findings:
- All three patients achieved excellent in-hospital outcomes.
- Patients were asymptomatic upon discharge.
- Fibrinolytic therapy proved a viable alternative to emergency surgical intervention in these cases.
Implications:
- Fibrinolytic drugs represent a valuable therapeutic option for diverse non-coronary embolic and thrombotic events.
- This approach may reduce the need for invasive surgical procedures.
- Further research into fibrinolytic therapy for non-coronary diseases is warranted.