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Published on: October 14, 2021
[Gene expression profile of the peripheral CD4(+)T cells in patients with RF(+) and RF(-) rheumatoid arthritis]
Cheng Lu1, Shi-jie Xu, Cheng Xiao
1Institute of Basic Research in Chinical Medicine, Beijing 100700, China. lv_cheng0816@163.com
Aim:
To explore the differences of the gene expression of CD4(+) lymphocytes between the RF(+) and RF(-) patients with rheumatoid arthritis.
Methods:
mRNA of all the CD4(+) lymphocytes samples were extracted and identified. Then they were labeled and hybridized to microarrays.
Results:
Hierarchical clustering analysis showed there were 55 differential expression genes between the RF(+) and RF(-) patients with rheumatoid arthritis.
Conclusion:
There are differential expression genes between the RF(+) and RF(-) patients and these genes are related to immunoresponse.
