Related Experiment Video
Updated: Jul 7, 2026
05:06
Robot-Assisted Laparoscopic Splenectomy In Children: A Case Report with Literature Review
Published on: March 27, 2026
Thromboembolism in children with lymphoma
Uma H Athale1, Kim Nagel, Anees A Khan
1Division of Hematology/Oncology, Department of Pediatrics, McMaster University, Hamilton, ON, Canada. athaleu@mcmaster.ca
Thrombosis Research
|February 2, 2008
Summary
Thrombosis is a frequent complication in pediatric lymphoma patients, affecting 12% of those studied. Mediastinal lymphadenopathy significantly increased thrombosis risk, highlighting the need for further research into pediatric cancer-related thrombosis.
Area of Science:
- Pediatric Oncology
- Hematology
- Clinical Epidemiology
Background:
- Thromboembolism is a significant concern in pediatric cancer.
- The specific epidemiology and risk factors for thrombosis in children with lymphoma remain poorly understood.
Purpose of the Study:
- To define the epidemiology of thrombosis in children diagnosed with lymphoma.
- To identify risk factors associated with thrombosis in this pediatric population.
Main Methods:
- Retrospective review of medical records for 75 children (<18 years) diagnosed with lymphoma between January 1990 and December 2004.
- Analysis of thrombotic events, including type, location, and association with central venous lines.
Main Results:
- 12% of patients (9 out of 75) experienced 16 thrombotic events; 75% were venous thrombosis, often linked to central venous lines.
- Patients with mediastinal lymphadenopathy had a significantly higher incidence of thrombosis (17.6%) compared to those without (0%).
- Recurrent clots and post-thrombotic syndrome were observed in 44% and 33.3% of affected patients, respectively.
Conclusions:
- Thrombosis is a common and morbid complication in pediatric lymphoma, with a high recurrence rate.
- Mediastinal mass is a significant risk factor for thrombosis in children with lymphoma.
- Further prospective studies are needed to confirm these findings and identify high-risk children.
Related Concept Videos
01:27Pulmonary Embolism III: Nursing Management
A pulmonary embolism occurs when a thrombus, amniotic fluid, tumor tissue, fat, or air embolus blocks one or more pulmonary arteries. Effective nursing management and patient education are crucial for improving outcomes and preventing recurrence.Nursing management starts with obtaining a comprehensive patient history, particularly noting any history of deep vein thrombosis (DVT). Assess for clinical manifestations, including dyspnea, chest pain, crackles, heart murmurs, and signs of right-sided...
01:29Venous Thrombosis III: Interprofessional Care
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
01:30Venous Thrombosis IV: Nursing Management
Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
01:29Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care
Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
01:29Pulmonary Embolism I: Introduction
Pulmonary embolism (PE) occurs when a thrombus, fat or air embolus, amniotic fluid, or tumor tissue blocks one or more pulmonary arteries. These blockages originate in the venous system or the right side of the heart.EtiologyPE primarily arises from deep vein thrombosis (DVT) and other hypercoagulable states, such as inherited thrombophilias. Additional etiological factors include venous stasis, commonly seen in obesity, and endothelial injury from surgery and trauma. Less common causes include...
01:19Pulmonary Embolism I: Introduction
A blood clot, or thrombus, is a semi-solid mass composed of fibrin, platelets, and red blood cells. When it forms within a vessel, it can obstruct blood flow, known as thrombosis. If part of the clot detaches, it becomes an embolus that can travel and block distant vessels. When this occurs in the pulmonary arteries, it causes a condition known as pulmonary embolism (PE).Origin and ImpactMost often, the embolus originates from a thrombus in the deep veins of the lower limbs, a condition called...