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Updated: Aug 10, 2026

Isolation of Brain-infiltrating Leukocytes
Published on: June 13, 2011
[Histiocytic medullary reticulosis and herpetic necrotizing inclusion hepatitis]
Abstract:
A male aged 47 suffered from the syndrome of histiocytic medullary reticulosis terminating lethally within one year. Because of the finding of a necrotizing inclusion hepatitis of the herpetic type at autopsy, intranuclear inclusions were retrospectively searched for in the tumour tissue. Inclusions were found, on the one hand, in a bioptic sample obained from a lymph node at the beginning of the disease and, on the other hand, in lympatic tissue and bone marrow obtained at autopsy. The relation of histiocytic medullary reticulosis to the herpetic infection has been discussed.
Insights
Histiocytic medullary reticulosis, a fatal condition, was linked to a herpetic infection. Intranuclear inclusions, indicative of herpesvirus, were found in tumor tissue, suggesting a viral etiology for this rare cancer.
Area of Science:
- Oncology
- Virology
- Pathology
Background:
- Histiocytic medullary reticulosis is a rare and aggressive hematologic malignancy.
- The etiology of histiocytic medullary reticulosis remains largely unknown.
- Herpesvirus infections are common and can cause various clinical manifestations.
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