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Serum creatinine stabilization following renal artery stenting

Mark C Bates1, John E Campbell, Mike Broce

  • 1Vascular Center of Excellence, Charleston Area Medical Center Research Institute, Charleston, WV, USA. mbates@camc.org

Vascular and Endovascular Surgery
|February 2, 2008
PubMed

Insights

Renal artery stenting stabilized or improved kidney function in 72% of patients with atherosclerotic renal artery stenosis. Bilateral stenting showed added benefits for long-term renal function.

Area of Science:

  • Cardiovascular Medicine
  • Nephrology
  • Interventional Radiology

Background:

  • Atherosclerotic renal artery stenosis (ARAS) can lead to progressive kidney function decline.
  • Renal artery stenting is a common intervention for ARAS, but its long-term impact on renal function requires further definition.

Purpose of the Study:

  • To evaluate the effect of renal artery stenting on renal function in patients with de novo atherosclerotic renal artery stenosis.
  • To identify predictors of renal function improvement or stabilization after stenting.

Main Methods:

  • Retrospective analysis of consecutive de novo ARAS patients undergoing renal artery stenting.
  • Exclusion of patients with inadequate pre- or post-procedure renal function data.
  • Definition of abnormal baseline serum creatinine (sCr) as > or = 1.5 mg/dL and categorization of follow-up sCr changes.

Main Results:

  • Renal function stabilized or improved in 72% of the 194-patient cohort.
  • A decline in renal function before stenting was followed by stabilization post-procedure.
  • Bilateral renal artery stenting predicted normal follow-up sCr.
  • Baseline sCr >2.1 mg/dL was associated with long-term sCr improvement.

Conclusions:

  • Renal artery stenting generally leads to stabilization of renal function in patients with ARAS.
  • Bilateral renal artery stenting appears to offer additional benefits for preserving renal function.

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