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Real-time Imaging of Myeloid Cells Dynamics in ApcMin/+ Intestinal Tumors by Spinning Disk Confocal Microscopy
Published on: October 6, 2014
Effect of exercise on biological pathways in ApcMin/+ mouse intestinal polyps
Kristen A Baltgalvis1, Franklin G Berger, Maria Marjorette O Peña
1Univ. of South Carolina, Dept. of Exercise Science, Rm. 405A Public Health Research Bldg., 921 Assembly St., Columbia, SC 29208, USA. carsonj@sc.edu
Journal of Applied Physiology (Bethesda, Md. : 1985)
|February 2, 2008
Summary
Regular exercise, like treadmill training, can reduce colorectal cancer risk by altering cellular signaling pathways in intestinal polyps. This study shows exercise impacts inflammation, apoptosis, and beta-catenin signaling in Apc(Min/+) mice.
Area of Science:
- Oncology
- Exercise Physiology
- Molecular Biology
Background:
- Epidemiological studies link exercise to reduced colorectal cancer risk.
- Treadmill training reduces polyp size and number in Apc(Min/+) mice, but mechanisms are unclear.
Purpose of the Study:
- To investigate how exercise training modulates cellular signaling pathways involved in tumor formation and growth within Apc(Min/+) mouse intestinal polyps.
Main Methods:
- Apc(Min/+) mice were divided into control and exercise groups.
- Exercised mice underwent 9 weeks of moderate-intensity treadmill training.
- Polyp tissues were analyzed for markers of inflammation, apoptosis, and beta-catenin signaling.
Main Results:
- Exercise training decreased macrophage infiltration by 35%.
- Apoptosis markers (TUNEL-positive cells) decreased by 73% and Bax protein by 43%.
- Beta-catenin phosphorylation increased 3.3-fold in polyps from exercised mice.
Conclusions:
- Moderate-intensity exercise alters cellular pathways in Apc(Min/+) mouse polyps.
- These alterations may explain the exercise-induced reduction in polyp formation and growth.
