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Related Experiment Video

Updated: Jul 7, 2026

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
04:30

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis

Published on: May 14, 2013

Does carotid stent cell design matter?

Martin Schillinger1, Manfred Gschwendtner, Bernhard Reimers

  • 1Department of Angiology, Medical University Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria. martin.schillinger@meduniwien.ac.at

Stroke
|February 2, 2008
PubMed
Summary
This summary is machine-generated.

Carotid stent cell design does not significantly impact neurologic complications or mortality. This study found no evidence that closed-cell or open-cell stent designs offer superior safety outcomes after carotid artery stenting.

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Last Updated: Jul 7, 2026

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Published on: September 18, 2015

Area of Science:

  • Cardiovascular Medicine
  • Interventional Neurology
  • Biomedical Engineering

Background:

  • Carotid stent cell design is a potential factor influencing neurologic complications.
  • Investigating stent design's impact on periprocedural and early postprocedural outcomes is crucial.

Purpose of the Study:

  • To compare the safety and efficacy of closed-cell versus open-cell carotid stent designs.
  • To evaluate the impact of stent cell design on neurologic adverse events and mortality.

Main Methods:

  • A study of 1684 patients undergoing carotid artery stenting across 10 European centers.
  • Analysis of neurologic events (transient ischemic attack, stroke) and mortality within 30 days, comparing closed-cell and open-cell stent designs.
  • Propensity-score-adjusted multivariable analysis was employed to assess outcomes.

Main Results:

  • No significant differences in combined transient ischemic attack, stroke, or death rates between closed-cell (6.1%) and open-cell (4.1%) designs.
  • Stroke or death rates within 30 days were also not significantly different (3.1% vs. 2.4%).
  • Adjusted analysis confirmed no differential risk for acute or subacute neurologic complications based on stent cell design.

Conclusions:

  • Current evidence does not support the superiority of a specific carotid stent cell design.
  • Neither closed-cell nor open-cell designs demonstrate a significant advantage regarding neurologic complications, stroke, or mortality risk.
  • Further research may be needed to fully elucidate any subtle differences or specific patient subgroup benefits.