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Related Concept Videos

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...
Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin studies.
Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
Schizophrenia01:17

Schizophrenia

Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those diagnosed.
Positive Symptoms of Schizophrenia: Hallucinations and Delusions01:30

Positive Symptoms of Schizophrenia: Hallucinations and Delusions

Schizophrenia is a complex mental health disorder that can manifest with various positive symptoms, including thought, movement, and behavior disorders. These symptoms significantly disrupt cognitive and motor functions, leading to profound effects on an individual's ability to engage with the world.
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes loosely...
Negative and Cognitive Symptoms of Schizophrenia01:30

Negative and Cognitive Symptoms of Schizophrenia

Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...

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Related Experiment Video

Updated: Jul 7, 2026

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra
05:14

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

Metabolic comorbidity in schizophrenia.

Rajesh Jacob1, Arabinda Narayan Chowdhury

  • 1Kettering Community Mental Health Team, Kettering, Northamptonshire Healthcare NHS Trust, Northampthonshire, United Kingdom. rajeshjacob28@hotmail.com

Indian Journal of Medical Sciences
|February 2, 2008
PubMed
Summary

Individuals with schizophrenia face higher risks of obesity, diabetes, and heart disease, often worsened by antipsychotic medications. Early identification and management of these metabolic risks are crucial for improving patient health.

Related Experiment Videos

Last Updated: Jul 7, 2026

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra
05:14

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

Area of Science:

  • Medical Science
  • Psychiatry
  • Public Health

Background:

  • Schizophrenia patients have increased risks of obesity, type 2 diabetes, hypertension, and dyslipidemia compared to the general population.
  • These conditions elevate cardiovascular disease incidence, leading to higher morbidity and mortality in schizophrenia patients.
  • Antipsychotic medications can exacerbate metabolic risks, increasing the likelihood of metabolic syndrome.

Purpose of the Study:

  • To review and recommend a framework for managing metabolic risks in schizophrenia patients.
  • To adapt existing guidelines for the Indian healthcare setting.
  • To improve the physical health outcomes for individuals with schizophrenia.

Main Methods:

  • Literature review of existing guidelines and studies.
  • Analysis of metabolic risk factors in schizophrenia.
  • Framework development for assessment, monitoring, and management.

Main Results:

  • Schizophrenia patients exhibit a significantly higher prevalence of metabolic abnormalities.
  • Antipsychotic use is a key contributor to metabolic syndrome in this population.
  • A structured approach to monitoring and management is essential.

Conclusions:

  • Proactive identification and management of metabolic risks are vital for schizophrenia patient care.
  • Implementing a tailored framework can mitigate cardiovascular risks and improve overall health.
  • This review provides a practical guide for clinicians in the Indian context.