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Published on: February 15, 2014
Preoperative identification of subthalamic nucleus for deep brain stimulation using three-dimensional phase sensitive
Takashi Ishimori1, Satoru Nakano, Yasutane Mori
1Department of Radiology, Faculty of Medicine, Kagawa University, Miki, Kita, Kagawa, Japan. ishimori@med.kagawa-u.ac.jp
Summary
Three-dimensional phase sensitive inversion recovery (IR) imaging is a feasible method for visualizing the subthalamic nucleus. This technique aids in accurately determining deep brain stimulator placement for effective treatment.
Area of Science:
- Neurosurgery
- Medical Imaging
- Radiology
Background:
- Accurate electrode placement is crucial for effective deep brain stimulation (DBS).
- Preoperative imaging plays a vital role in surgical planning for DBS procedures.
Purpose of the Study:
- To evaluate the feasibility of using three-dimensional (3D) phase sensitive inversion recovery (IR) magnetic resonance imaging (MRI) for precise preoperative localization of the subthalamic nucleus (STN).
- To assess the accuracy of 3D phase sensitive IR in determining deep brain stimulator position.
Main Methods:
- Geometric distortion was quantified using a grid phantom.
- Optimal imaging parameters for 3D phase sensitive IR were determined through evaluation of volunteer images.
- The technique was applied to 3 volunteers and 2 patients undergoing DBS surgery.
Main Results:
- Geometric distortion was found to be less than 1.0%.
- Optimal inversion and recovery times (200 and 4000 ms, respectively) provided excellent T1 contrast between the STN and surrounding tissues.
- The STN was clearly visualized in all subjects, and its coordinates correlated well with conventional methods.
Conclusions:
- Three-dimensional phase sensitive IR MRI is a valuable tool for visualizing the STN.
- This imaging modality facilitates accurate targeting for effective deep brain stimulation surgery.
