Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Apolipoprotein D--an atypical apolipoprotein.

P K Weech1, P Provost, N M Tremblay

  • 1Merck Frosst Centre for Therapeutic Research, Merck Frosst Canada Inc., Pointe Claire-Dorval, Québec.

Progress in Lipid Research
|January 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The protein l-isoaspartyl (d-aspartyl) methyltransferase protects against dopamine-induced apoptosis in neuroblastoma SH-SY5Y cells.

Neuroscience·2015
Same author

Dopamine down-regulation of protein L-isoaspartyl methyltransferase is dependent on reactive oxygen species in SH-SY5Y cells.

Neuroscience·2014
Same author

MFSD2a, the Syncytin-2 receptor, is important for trophoblast fusion.

Placenta·2012
Same author

Cardiac masses in a patient with AJCC stage II melanoma: cautious interpretation of the magnetic resonance imaging.

Clinical and experimental dermatology·2010
Same author

[Pruritus: diagnostic strategy and therapeutic approach].

Revue medicale de Bruxelles·2009
Same author

[The treatment of psoriasis: basic principles and new options].

Revue medicale de Bruxelles·2007

Apolipoprotein D (ApoD) structure and synthesis sites are identified, differing from other apolipoproteins. Its role in lipid transport and organ homeostasis is under investigation, with potential implications beyond cardiovascular disease.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Physiology

Background:

  • Apolipoprotein D (ApoD) is a protein with unique structural and synthesis characteristics compared to other apolipoproteins.
  • Its precise function within the plasma lipoprotein system is not fully elucidated.
  • Recent advancements reveal its potential significance in organ homeostasis and cellular housekeeping.

Purpose of the Study:

  • To describe the structure and synthesis sites of Apolipoprotein D (ApoD).
  • To explore the potential roles of ApoD in lipid transport and intercellular communication.
  • To investigate the upregulation of ApoD during nerve regeneration.

Main Methods:

  • Structural analysis of ApoD.
  • Investigation of ApoD synthesis locations.

Related Experiment Videos

  • Ligand binding assays (steroids, bilirubin).
  • Observation of ApoD expression during peripheral nerve regeneration.

    • Main Results:

    • ApoD's structure and synthesis sites have been identified and found to be distinct from other apolipoproteins.
    • ApoD likely functions in the unidirectional transport of hydrophobic ligands, such as lipids, between cells.
    • ApoD binds to certain steroids and bilirubin.
    • Significant upregulation of ApoD synthesis occurs during peripheral nerve regeneration.

    Conclusions:

    • ApoD possesses unique biochemical properties differentiating it from other apolipoproteins.
    • ApoD is implicated in intercellular lipid transport and may play a crucial role in organ homeostasis.
    • Further research into ApoD's physiological functions is warranted, potentially revealing its importance in diverse biological processes, including nerve repair.