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All-cause and cardiovascular disease mortality increased with metabolic syndrome in Taiwanese

Kuo-Chin Huang1, Long-Teng Lee, Ching-Yu Chen

  • 1Department of Family Medicine, National Taiwan University Hospital, Taipei, Taiwan. chin3@ha.mc.ntu.edu.tw

Obesity (Silver Spring, Md.)
|February 2, 2008
PubMed

Insights

Metabolic syndrome increases mortality risk in Taiwanese adults. Both AHA/NHLBI and IDF definitions show a significant association with all-cause and cardiovascular disease mortality, highlighting a critical public health concern.

Area of Science:

  • Cardiology
  • Endocrinology
  • Public Health

Background:

  • Metabolic syndrome is a cluster of conditions that increase the risk of heart disease, stroke, and type 2 diabetes.
  • Prevalence and mortality associations of metabolic syndrome vary across different ethnic groups.
  • The America Heart Association/National Heart Lung Blood Institute (AHA/NHLBI) and International Diabetes Federation (IDF) provide distinct definitions for metabolic syndrome.

Purpose of the Study:

  • To investigate the relationship between metabolic syndrome and mortality in a Taiwanese population.
  • To compare the predictive value of AHA/NHLBI and IDF definitions of metabolic syndrome for mortality outcomes.
  • To assess the association of metabolic syndrome with all-cause and cardiovascular disease (CVD) mortality.

Main Methods:

  • A cohort of 124,513 Taiwanese adults (aged 20-94) was followed for 8 years.
  • Cox proportional hazard regression analyses were employed to estimate relative risks (RRs) for mortality.
  • Metabolic syndrome was defined using both AHA/NHLBI and IDF criteria.

Main Results:

  • The prevalence of metabolic syndrome was 22.4% (AHA/NHLBI) and 13.9% (IDF).
  • Metabolic syndrome was associated with increased all-cause and CVD mortality, with higher risks observed using the AHA/NHLBI definition.
  • Associations remained significant even after excluding participants with baseline diabetes or CVD.

Conclusions:

  • Metabolic syndrome is prevalent in Taiwanese adults and significantly associated with increased mortality.
  • Both AHA/NHLBI and IDF definitions identify metabolic syndrome as a risk factor for death.
  • The findings suggest that metabolic syndrome poses a substantial mortality risk in Asian populations, similar to Western cohorts.
Abstract

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