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Published on: October 29, 2013
Conformation and kinetic characteristics of interactions between local anesthetics and aqueous solutions of
A P Galenko-Yaroshevskii1, I A Varlashkina, Kh P Takhchidi
1Krasnodar Affiliated Department of Southern Bureau of Russian Academy of Medical Sciences, Moscow, Russia.
Abstract:
Conformation and kinetic characteristics of the interactions of local anesthetics lidocaine (xycaine), tetracaine (dicaine), bupivacaine, and new RU-1117 compound with proven anesthetic activity with Visiton (1% hydroxypropylmethylcellulose in phosphate buffer) were studied. It was found that complex formation between the local anesthetics and hydroxypropylmethylcellulose is a time-dependent reversible process. The equilibrium is attained within 2.5-8.0 h and depends on the chemical nature of local anesthetic.
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