Related Experiment Videos
[DNA-breaking action of ascorbic acid in the presence of Cu(II)/demethylcantharic acid complex]
1Physical Chemistry Department, School of Pharmaceutical Sciences, Beijing Medical University.
Yao Xue Xue Bao = Acta Pharmaceutica Sinica
|January 1, 1991
Abstract:
Effects of various factors on the DNA-breaking action of ascorbic acid in the presence of Cu(II)/demethylcantharic acid complex were studied in phosphate buffer (pH 7.40), at 37.0 +/- 0.1 degrees C. It was shown that .OH produced from Fenton reaction of H2O2 which can be formed from the oxidation of ascorbic acid was responsible for the DNA-breaking action of ascorbic acid and the simple Fenton reaction cannot explain all the results.