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Analysis of Beta-cell Function Using Single-cell Resolution Calcium Imaging in Zebrafish Islets
Published on: July 3, 2018
RyR channels and glucose-regulated pancreatic beta-cells
Xuan Zhan1, Lijian Yang, Ming Yi
1Department of Physics and Institute of Biophysics, Central China Normal University, 430079, Wuhan, China. zhanx@phy.ccnu.edu.cn
Abstract:
Ryanodine receptor channel model is introduced to a dynamical model of pancreatic beta-cells to discuss the effects of RyR channels and glucose concentration on membrane potential. The results show Ca2+ concentration changes responding to enhance of glucose concentration is more quickly than that of activating RyR channels, and both methods can induce bursting action potential and increase free cytosolic Ca2+ concentration. An interesting finding is that moderate stimulation to RyR channels will result in a kind of "complex bursting", which is more effective in enhancing average Ca2+ concentration and insulin section.
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