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[Effects of berberine on synthesis of platelet TXA2 and plasma PGI2 in rabbits]
1Department of Biochemistry, Second Military Medical University, Shanghai, China.
Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica
|November 1, 1991
Abstract:
Using radioimmunoassay, we found that berberine (0.50 mol.L-1) inhibited dose-dependently collagen-, ADP-, and arachidonic acid (AA)-induced TXA2 release from platelets. Berberine (25 mg.kg-1) iv lowered rabbit plasma level of PGI2 from 0.92 +/- 0.20 to 0.61 +/- 0.08 ng.ml-1 after 60 min. The results suggest that berberine inhibits AA release from cell membrane phospholipids and its metabolism.