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Updated: Jul 7, 2026

A Preterm Rat Model for Pain Studies
Published on: February 9, 2024
[Pharmacologic and non-pharmacologic pain-therapy in neonatology: synopsis of the current data]
1Bereich Neonatologie, Kinderklinik des Klinikums der Universität zu Köln, Köln. christoph.huenseler@uni-koeln.de
Insights
Neonatal pain management is crucial for preterm and term infants, despite its prevalence in neonatal intensive care. This review evaluates current pain relief strategies for common neonatal procedures.
Area of Science:
- Neonatalogy
- Pain Medicine
- Pediatric Intensive Care
Context:
- Early pain experiences negatively impact preterm and term neonates' acute and long-term outcomes.
- Pain is frequently encountered in neonatal intensive care settings.
- Existing pain therapies, both pharmacologic and nonpharmacologic, show variable efficacy.
Purpose:
- To provide a comprehensive overview of current pain management strategies for neonates undergoing invasive procedures.
- To evaluate the benefits and drawbacks of various pain alleviation methods for neonates.
Summary:
- This article reviews pain management techniques for neonates during endotracheal suctioning, eye examinations, and mechanical ventilation.
- It assesses the efficacy and safety of different pharmacologic and nonpharmacologic interventions.
- The review aims to guide clinical practice in neonatal pain control.
Impact:
- Improved understanding of neonatal pain management can lead to better patient outcomes.
- Evidence-based strategies can optimize pain relief for vulnerable neonates.
- This review supports the development of standardized pain protocols in neonatal intensive care.
Background:
There is increasing knowledge about the negative consequences of early pain experiences on the acute and long-term outcome of preterm and term neonates. Despite of it, pain is common in neonatal intensive care. Pharmacologic and nonpharmacologic methods of pain therapy with variable analgesic efficacy exist.
Method:
The aim of this article is to give a compendium of the actual strategies of pain therapies for invasive procedures, endotracheal suctioning, eye-examination and for mechanical ventilation of preterm and term neonates. An evaluation of benefits and drawbacks of the single pain alleviating measures will be done.
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