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Updated: Jul 7, 2026

Atomic Force Microscopy Investigations of DNA Lesion Recognition in Nucleotide Excision Repair
Published on: May 24, 2017
[Structure and conformational dynamics of base excision repair DNA glycosylases]
Abstract:
DNA glycosylases are key enzymes participating in the process of DNA repair, which maintains the integrity of the cellular genome. Currently, structures for many of these enzymes have been solved. This review is devoted to the analysis of these structures and the dynamics of the interactions of DNA glycosylases with DNA. The available data suggest that lesion recognition by DNA glycosylases is a highly dynamic process accompanied with multiple conformational changes in the enzyme and the DNA substrate molecules.
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