Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Photoreceptors and Visual Pathways

Photoreceptors and Visual Pathways

At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category, whereas...

Accessory Structures of the Eye

Accessory Structures of the Eye

Optical perception, or vision, is an extraordinary sense dependent on converting light signals received via the ocular organs. These organs, known as eyes, are securely positioned within the bony cavities of the skull, called orbits. The orbits serve a dual purpose: a protective shield for the ocular globes and a stable attachment point for the soft ocular tissues. The eye's external protective mechanisms include the eyelids, which are edged with lashes that act as a barrier against foreign...

Glaucoma: Overview

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...

Microbiome of the Eye

Microbiome of the Eye

The human eye has a specialized microbiota that reflects its unique anatomical and immunological environment. This low-biomass microbial community predominantly colonizes the conjunctiva and eyelid margins, playing a vital role in ocular surface homeostasis and defense. Despite its proximity to the richly colonized facial skin, the ocular surface maintains a distinct microbial profile due to continuous mechanical and biochemical defense mechanisms.The conjunctival surface hosts fewer microbial...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

<i>cis</i>-/<i>trans</i>-Specific Synthesis of Functionalized Bottlebrush Ring Opening Metathesis Polymerization Polymers Containing Terthiophene and Pyrene That Exhibit Unique Thermal and Emission Properties.

ACS macro letters·2025

Same author

Neuronal Intranuclear Inclusion Disease with a Corneal Disorder: A Case Report.

Medicina (Kaunas, Lithuania)·2024

Same author

Both hemoglobin and hemin cause damage to retinal pigment epithelium through the iron ion accumulation.

Journal of pharmacological sciences·2024

Same author

An Aqueous Redox Flow Battery Using CO<sub>2</sub> as an Active Material with a Homogeneous Ir Catalyst.

Angewandte Chemie (International ed. in English)·2023

Same author

Electrochemistry in bicontinuous microemulsions derived from two immiscible electrolyte solutions for a membrane-free redox flow battery.

Journal of colloid and interface science·2023

Same author

Redox Reaction in Ti-Mn Redox Flow Battery Studied by X-ray Absorption Spectroscopy.

Chemistry, an Asian journal·2022

Search research articles

Related Experiment Video

Updated: Jul 7, 2026

Assessment of Oxidative Damage in the Primary Mouse Ocular Surface Cells/Stem Cells in Response to Ultraviolet-C (UV-C) Damage

Assessment of Oxidative Damage in the Primary Mouse Ocular Surface Cells/Stem Cells in Response to Ultraviolet-C (UV-C) Damage

Published on: February 15, 2020

[Oxidative stress in ocular disease].

Akihiro Ohira¹, Toshihiko Ueda, Kentaro Ohishi

¹Department of Ophthalmology, Shimane University School of Medicine, Izumo, Japan. aohira@med.shimane-u.ac.jp

Nippon Ganka Gakkai Zasshi

|February 5, 2008

Summary

Oxidative stress, caused by free radicals, damages cells and contributes to eye diseases like age-related macular degeneration (AMD). Cataract surgery may reduce lipid peroxidation in the eye.

More Related Videos

Quantification of Reactive Oxygen Species Using 2′,7′-Dichlorofluorescein Diacetate Probe and Flow-Cytometry in Müller Glial Cells

Quantification of Reactive Oxygen Species Using 2′,7′-Dichlorofluorescein Diacetate Probe and Flow-Cytometry in Müller Glial Cells

Published on: May 13, 2022

Analysis of Oxidative Stress in Zebrafish Embryos

Analysis of Oxidative Stress in Zebrafish Embryos

Published on: July 7, 2014

Related Experiment Videos

Last Updated: Jul 7, 2026

Assessment of Oxidative Damage in the Primary Mouse Ocular Surface Cells/Stem Cells in Response to Ultraviolet-C (UV-C) Damage

Assessment of Oxidative Damage in the Primary Mouse Ocular Surface Cells/Stem Cells in Response to Ultraviolet-C (UV-C) Damage

Published on: February 15, 2020

Quantification of Reactive Oxygen Species Using 2′,7′-Dichlorofluorescein Diacetate Probe and Flow-Cytometry in Müller Glial Cells

Quantification of Reactive Oxygen Species Using 2′,7′-Dichlorofluorescein Diacetate Probe and Flow-Cytometry in Müller Glial Cells

Published on: May 13, 2022

Analysis of Oxidative Stress in Zebrafish Embryos

Analysis of Oxidative Stress in Zebrafish Embryos

Published on: July 7, 2014

Area of Science:

Ocular biochemistry and pathology
Cellular degeneration mechanisms

Context:

Oxidative stress, characterized by excess free radicals, leads to cellular degeneration and lipid peroxidation.
This process is implicated in various ocular diseases, including age-related macular degeneration (AMD), retinopathy of prematurity, and cataracts.

Purpose:

To explore the role of oxidative stress and reactive oxygen species in ocular disease pathogenesis.
To investigate the potential impact of environmental factors like light and iron on AMD progression.
To examine the effects of gamma irradiation on ciliary body cells and the implications for intraocular lens (IOL) technology.

Summary:

Oxidative stress and free radical imbalance cause cellular damage, contributing to ocular conditions like AMD and cataracts.
Studies show gamma irradiation affects cellular apoptosis and BCL2 expression in the ciliary body.
While UV light exposure is linked to AMD, cataract surgery's effect on AMD progression is debated, though some studies indicate reduced lipid peroxidation post-surgery.

Impact:

Understanding oxidative stress mechanisms can inform strategies for preventing or treating ocular diseases.
Research into light absorption by IOLs may lead to improved cataract surgery outcomes and AMD prevention.
Further investigation is needed to clarify the relationship between cataract surgery and AMD.