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Updated: Jul 7, 2026

Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
Published on: November 29, 2024
Application of metabonomics in drug development
Hector C Keun1, Toby J Athersuch
1Imperial College London, Department of Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics (SORA), Faculty of Medicine, South Kensington, London, SW7 2AZ, UK. h.keun@imperial.ac.uk
Metabolic profiling, or metabonomics, analyzes biological samples to discover biomarkers. This untargeted approach aids drug development and personalized healthcare through robust analytical methods.
Area of Science:
- Biochemistry
- Analytical Chemistry
- Pharmacology
Background:
- Metabolic profiling (metabonomics/metabolomics) involves untargeted analysis of biological samples for biomarker discovery.
- Noninvasive biofluid analysis is suitable for clinical settings and dynamic monitoring.
- Metabolite identity ensures robust analytical protocols for translational research.
Purpose of the Study:
- To review the latest developments in metabonomics and its applications in drug development.
- To highlight the impact of new data and analytical techniques in the field.
- To discuss future goals for biomarker validation and personalized healthcare.
Main Methods:
- Untargeted analysis of metabolic composition.
- Noninvasive biofluid analysis.
- Review of current data and chemical analytical techniques.
Main Results:
- Metabonomics impacts drug development from target identification to clinical monitoring.
- Analytical protocols are robust due to the universal nature of metabolites.
- New data and techniques are advancing the field.
Conclusions:
- Metabonomics is a powerful tool for biomarker discovery and drug development.
- Future goals include biomarker validation and advancing personalized healthcare.
- The field facilitates bench-to-bedside translational research.
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