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Related Concept Videos

Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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Combination Therapies and Personalized Medicine

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Cancer

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Modern Molecular Taxonomy

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Related Experiment Video

Updated: Jul 7, 2026

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies
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Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies

Published on: April 11, 2016

Molecular oncology: current trends in diagnostics.

Joel A Lefferts1, Claudine L Bartels, Gregory J Tsongalis

  • 1Dartmouth Medical School, Department of Pathology, Dartmouth-Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756, USA.

Future Oncology (London, England)
|February 5, 2008
PubMed
Summary

Molecular diagnostics are now clinically useful in oncology, aiding in cancer diagnosis and patient management. This study highlights BCR-ABL testing for chronic myelogenous leukemia and sentinel lymph node analysis for breast cancer.

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Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies
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Published on: October 18, 2013

Area of Science:

  • Clinical Molecular Diagnostics
  • Oncology
  • Cancer Genomics

Background:

  • Molecular diagnostics in oncology have lagged behind research discoveries.
  • Technical advancements from infectious disease testing enable new cancer applications.
  • Recent progress facilitates clinical utility of molecular findings in tumorigenesis.

Purpose of the Study:

  • To demonstrate the clinical utility of molecular diagnostic techniques in routine settings.
  • To showcase advancements in molecular assays for oncology.
  • To illustrate the application of molecular diagnostics in patient care.

Main Methods:

  • Utilized established molecular techniques adapted from infectious disease diagnostics.
  • Developed and applied qualitative, quantitative, and genotyping assays.
  • Examined two specific clinical cases: BCR-ABL assessment and sentinel lymph node analysis.

Main Results:

  • Successfully applied molecular diagnostics to assess BCR-ABL in chronic myelogenous leukemia.
  • Demonstrated effective detection of tumor cells in sentinel lymph nodes of breast cancer patients.
  • Validated the role of molecular techniques in clinical decision-making.

Conclusions:

  • Molecular diagnostics are increasingly valuable in clinical oncology.
  • Specific applications like BCR-ABL and sentinel lymph node analysis show significant clinical impact.
  • Molecular techniques are transitioning effectively into routine clinical practice for cancer management.