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7. Immunologic lung disease.

Paul A Greenberger1

  • 1Division of Allergy-Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. p-greenberger@northwestern.edu

The Journal of Allergy and Clinical Immunology
|February 5, 2008
PubMed
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This review explores lung immune responses, including innate and adaptive immunity. It covers World Trade Center cough, acute respiratory distress syndrome, and immunologic lung conditions.

Area of Science:

  • Pulmonary immunology
  • Infectious disease

Background:

  • The lung is a complex organ responding to various inhaled or systemic exposures.
  • Immune responses can lead to airway constriction or parenchymal lung damage.

Purpose of the Study:

  • To review pulmonary innate and adaptive immune responses.
  • To discuss World Trade Center cough, a new condition with asthma-like symptoms.
  • To cover diagnosis and treatment of immunologic lung conditions.

Main Methods:

  • Literature review of pulmonary immunology.
  • Focus on innate and adaptive immune mechanisms.
  • Discussion of specific conditions like WTC cough and ARDS.

Main Results:

  • Innate immunity is crucial in acute respiratory distress syndrome and transfusion-related acute lung injury.

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  • Adaptive immunity involves lymphocytes and antibodies, with CD4+ TH1/TH2 phenotypes relevant to tuberculosis and asthma.
  • Conclusions:

    • Understanding pulmonary immune responses is vital for managing diverse lung conditions.
    • WTC cough presents similarly to reactive airways dysfunction syndrome.
    • Specific immune pathways dictate outcomes in various lung diseases.