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Worm thermotaxis: a model system for analyzing thermosensation and neural plasticity

Ikue Mori1, Hiroyuki Sasakura, Atsushi Kuhara

  • 1Laboratory of Molecular Neurobiology, Department of Molecular Biology, Graduate School of Science, Nagoya University, Nagoya 464-8602, Japan. m46920a@nucc.cc.nagoya-u.ac.jp

Current Opinion in Neurobiology
|February 5, 2008
PubMed

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Thermosensation

Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...