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Updated: Jul 7, 2026

A Syngeneic Mouse B-Cell Lymphoma Model for Pre-Clinical Evaluation of CD19 CAR T Cells
Published on: October 16, 2018
Harnessing serotonergic and dopaminergic pathways for lymphoma therapy: evidence and aspirations
Nicholas M Barnes1, John Gordon
1Division of Neuroscience, The Medical School, Vincent Drive, Birmingham B15 2TT, United Kingdom. n.m.barnes@bham.ac.uk
Abstract:
Growing evidence supports the notion that pharmaceutical targeting of the 5-hydroxytryptamine (5-HT) and dopamine (DA) systems offers the potential to treat human immune system disorders. This review describes this emerging area of research, which has the benefit of being supported by a relatively detailed understanding of these monoamine systems within other tissues of the body. Furthermore, the availability of a number of pharmaceutical agents originally developed to manipulate central monoamine function, offer many suitable drug candidates to test their therapeutic potential in the immune pathology arena.
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