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Published on: December 10, 2013

WU polyomavirus in children with acute lower respiratory tract infections, China

Feng Lin1, Meiyun Zheng, Hua Li

  • 1Wenzhou Medicine College, Wenling First Hospital, Wenling, Zhejiang Province, Wenling, China. linfengwyy@vip.sina.com

Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
|February 5, 2008
PubMed

Insights

WU polyomavirus (WUPyV) was detected in Chinese children, confirming its presence in respiratory secretions. This finding contributes to understanding WUPyV

Area of Science:

  • Virology
  • Molecular Biology
  • Pediatrics

Background:

  • WU polyomavirus (WUPyV), a novel polyomavirus, is linked to respiratory infections.
  • The clinical significance and pathogenicity of WUPyV remain largely unknown.

Purpose of the Study:

  • To confirm the presence of WU polyomavirus in a pediatric population in China.
  • To identify WUPyV in nasopharyngeal aspirate samples from children.

Main Methods:

  • Polymerase Chain Reaction (PCR) was employed for WUPyV detection.
  • Nasopharyngeal aspirate specimens from 278 children were analyzed.
  • PCR products were directly sequenced for precise identification.

Main Results:

  • WU polyomavirus was identified in one out of 278 nasopharyngeal aspirates (0.4% positivity rate).
  • Sequencing confirmed the detected WUPyV strains were identical to prototype strains.
  • The genome, Large T-antigen (LTAg), and VP2 gene sequences matched reference WUPyV.

Conclusions:

  • This study confirms the presence of WU polyomavirus in respiratory secretions in China.
  • The findings provide initial evidence of WUPyV circulation in the Chinese pediatric population.
Abstract

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