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Updated: Jul 7, 2026

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
Published on: October 27, 2020
A possible link between resveratrol and TGF-beta: resveratrol induction of TGF-beta expression and signaling
Fumiko Suenaga1, Kyosuke Hatsushika, Shinichi Takano
1Department of Immunology, Faculty of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan.
Abstract:
Resveratrol, a polyphenolic compound found in the skin of red fruits, exhibits anti-inflammatory, anti-oxidative, and anti-proliferative characteristics. Transforming growth factor-beta (TGF-beta) is a pleiotropic cytokine that also displays such properties. We therefore hypothesized that there might be a functional link between resveratrol and TGF-beta. This study reports that resveratrol increased transcription of the TGF-beta2 gene, enhanced the production of TGF-beta2 protein, and activated Smad signaling in an autocrine manner in A549 human lung epithelial cell line. Thus, some of the beneficial effects of resveratrol on human health might be mediated, in part, through its effects on TGF-beta expression and signaling.
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