Cholestasis induced by total parenteral nutrition
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Updated: Jul 7, 2026

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
Published on: September 20, 2019
Francesco William Guglielmi1, Nunzia Regano, Silvia Mazzuoli
1Section of Gastroenterology & Artificial Nutrition, Hospital San Nicola Pellegrino, 70059 Trani, Bari, Italy. guglielmifw@libero.it
Abstract:
Parenteral nutrition is a life-saving treatment for patients who have acute and chronic intestinal failure. Severe cholestasis induced by total parental nutrition (TPN-IC) is characterized by bile duct regeneration, portal inflammation, and fibrosis. Its progression could be very rapid, and in some patients liver cirrhosis may develop in few months. This article describes the definition, incidence, hepatic changes, histopathologic findings, risk factors, pathogenesis, and clinical implications of TPN-IC. The goal is to improve hospital and home management, quality of life, and prognosis of patients requiring parenteral nutrition.
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