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Updated: Jul 7, 2026

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
Published on: September 20, 2018
Dubbing SAGA unveils new epigenetic crosstalk
W W M Pim Pijnappel1, H Th Marc Timmers
1Department of Physiological Chemistry, STR3.201, University Medical Centre Utrecht, Universiteitsweg 100, Utrecht, The Netherlands.
Abstract:
In a recent issue of Molecular Cell, two independent studies (Zhang et al., 2008; Zhao et al., 2008) provide compelling evidence that targeted deubiquitylation of histones is intimately linked to transcription activation, epigenetic regulation, and cancer progression.
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