Dietary modulation of malaria infection in rats

Feeding of wistar albino rats on low protein and energy diet (4% protein) caused suppression of parasitaemia when infected with Plasmodium berghei besides causing a depressed immune response. The refeeding of protein energy deficient rats on normal protein and energy diet (18% protein) for four weeks resulted in the normal course of parasitaemia after P. berghei infection. The present study was carried out to find the cause of suppression of malaria in protein energy deficient rats. The experiments revealed re-elevation of malaria parasitaemia when rats were fed on low protein diets supplemented with p-amino-benzoic acid (PABA). Moreover, the parasite persisted at subpatent levels in tissues in protein energy deficient rats and resulted in the development of antimalarial antibodies. Low protein energy diet could cause deficiency of certain essential nutrients required for the parasite, PABA being one of them, and hence suppresses the parasitaemia to subpatent levels. As a result, sufficient antigenic stimulus is provided to the host so that the host develops an immune response which might in turn help in further suppression of parasitaemia to subpatent levels.