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Updated: Jul 7, 2026
Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
Published on: February 6, 2019
[Should chest wall irradiation be included after mastectomy and negative node breast cancer?]
C N Ben Ammar1, L Kochbati, N Chraeit
1Service de radiothérapie-oncologie, institut Salah-Azaiz, boulevard du 9 avril, 1006 Bab-Saadoun, Tunis, Tunisie. chiraz_ammar@yahoo.com
Purpose:
This study aims to evaluate local failure patterns in node negative breast cancer patients treated with post-mastectomy radiotherapy including internal mammary chain only.
Patients And Methods:
Retrospective analysis of 92 internal or central-breast node-negative tumours with mastectomy and external irradiation of the internal mammary chain at the dose of 50 Gy, from 1994 to 1998.
Results:
Local recurrence rate was 5 % (five cases). Recurrence sites were the operative scare and chest wall. Factors associated with increased risk of local failure were age < or = 40 years and tumour size greater than 20mm, without statistical significance.
Conclusion:
Post-mastectomy radiotherapy should be discussed for a sub-group of node-negative patients with predictors factors of local failure such as age < or = 40 years and larger tumour size.
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