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Related Concept Videos

Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
Mechanism of Angiogenesis01:10

Mechanism of Angiogenesis

Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
Radiation: Applications01:17

Radiation: Applications

The average temperature of Earth is the subject of much current discussion. Earth is in radiative contact with both the Sun and dark space; it receives almost all its energy from the radiation of the Sun and reflects some of it into outer space. Dark space is very cold, about 3 K, so Earth radiates energy into it. For instance, heat transfer occurs from soil and grasses, the rate of which can be so rapid that frost can occur on clear summer evenings, even in warm latitudes.
The average...
Biological Effects of Radiation02:59

Biological Effects of Radiation

All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they produce ions...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Cancer Therapies02:49

Cancer Therapies

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Phase I trial of everolimus in combination with thoracic radiotherapy in non-small-cell lung cancer.

Annals of oncology : official journal of the European Society for Medical Oncology·2015
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Implementation of the global risk analysis in pulsed-dose rate brachytherapy: methods and results.

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Focal or combined modality for the management of brain metastasis: did high tech radiotherapy superseded drug-radiotherapy combination?

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Related Experiment Video

Updated: Jul 7, 2026

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells
09:03

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells

Published on: November 23, 2014

[Angiogenesis: all a radiation oncologist should know].

R Mazeron1, J Bourhis, E Deutsch

  • 1UPRES EA2710, Laboratoire de Radiosensibilité des Tumeurs et des Tissus Sains, Institut Gustave-Roussy, 39, rue Camille-Desmoulins, Villejuif, France.

Cancer Radiotherapie : Journal De La Societe Francaise De Radiotherapie Oncologique
|February 5, 2008
PubMed
Summary

Tumor growth requires angiogenesis, the formation of new blood vessels. Novel anti-cancer therapies targeting angiogenesis show promise, especially when combined with radiotherapy.

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A Novel High-resolution In vivo Imaging Technique to Study the Dynamic Response of Intracranial Structures to Tumor Growth and Therapeutics
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Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
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Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

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Related Experiment Videos

Last Updated: Jul 7, 2026

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells
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A Novel High-resolution In vivo Imaging Technique to Study the Dynamic Response of Intracranial Structures to Tumor Growth and Therapeutics

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Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
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Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Published on: March 11, 2021

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Context:

  • Angiogenesis is essential for tumor growth, providing oxygen and nutrients.
  • Tumorigenesis and metastasis are complex processes regulated by multiple factors.
  • Novel anti-cancer therapies targeting angiogenesis are emerging.

Purpose:

  • To review the role of angiogenesis in tumor development.
  • To summarize current knowledge on antiangiogenic therapies.
  • To explore the potential of combining antiangiogenic agents with radiotherapy.

Summary:

  • Angiogenesis, the formation of new blood vessels, is vital for tumor growth and metastasis.
  • Antiangiogenic therapies have demonstrated efficacy in clinical trials and are approved treatments.
  • Current research focuses on combining antiangiogenic agents with radiotherapy for enhanced cancer treatment.

Impact:

  • Provides a comprehensive overview of angiogenesis in cancer.
  • Highlights the clinical significance of antiangiogenic therapies.
  • Informs future research on combination treatments involving antiangiogenesis and radiotherapy.