Related Experiment Video
Updated: Jul 7, 2026

09:26
Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication
Published on: February 6, 2019
Death in head-down position in a heavily intoxicated obese man
A De Donno1, A De Fazio, M G Greco
1Section of Legal Medicine, Di.M.I.M.P., P.zza Giulio Cesare n.11, University of Bari, 70124 Bari, Italy. antonio.dedonno@tin.it
Legal Medicine (Tokyo, Japan)
|February 5, 2008
Summary
Positional asphyxia in a head-down position is rare. Acute alcohol intoxication and obesity were identified as contributing factors in this rare case of death.
Area of Science:
- Forensic Pathology
- Toxicology
Background:
- Positional asphyxia is a rare cause of death, often presenting with subtle or absent morphological findings.
- This case report examines a unique instance of a 78-year-old man found deceased in a head-down position.
Observation:
- The deceased was found suspended by his leg in a blackberry bush, exhibiting cyanosis and petechial hemorrhages.
- Autopsy revealed pulmonary and cerebral edema, cardiac enlargement, and arterial calcification.
- Significant findings included acute alcoholic intoxication (blood alcohol concentration 2.10 g/l) and obesity (BMI 33.4).
Findings:
- The primary cause of death was positional asphyxia, exacerbated by acute alcohol intoxication.
- Obesity and pre-existing cardiovascular changes may have contributed to the fatal outcome.
- Toxicological screening for illicit drugs was negative, ruling out other common causes.
Implications:
- This case highlights the critical role of alcohol and obesity as co-factors in positional asphyxia deaths.
- It underscores the importance of thorough toxicological and pathological examination in unexplained deaths.
- Understanding these contributing factors is crucial for accurate forensic investigations.
Related Concept Videos
Drug Dosing: Obese Patients
In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
Acute Respiratory Failure-III
Hypercapnic respiratory failure, also known as Type 2 or ventilatory respiratory failure, is a severe condition characterized by the body's inability to effectively remove carbon dioxide (CO2) from the bloodstream. It leads to an arterial CO2 pressure (PaCO2) exceeding 45 mmHg and a blood pH above 7.35. This situation indicates that the body's ventilatory demand, or the ventilation needed to maintain normal PaCO2 levels, surpasses its supply or the maximum gas flow achievable without causing...
Hypothesis Test for Test of Independence
The test of independence is a chi-square-based test used to determine whether two variables or factors are independent or dependent. This hypothesis test is used to examine the independence of the variables. One can construct two qualitative survey questions or experiments based on the variables in a contingency table. The goal is to see if the two variables are unrelated (independent) or related (dependent). The null and alternative hypotheses for this test are:
H0: The two variables (factors)...
H0: The two variables (factors)...
Intestinal Obstruction II: Pathophysiology
Intestinal obstruction triggers a series of physiological responses, starting with gas and fluid accumulation in the bowel segment proximal to the obstruction, leading to distension. This distended intestine compresses the diaphragm, hindering lung expansion and potentially leading to reduced respiratory effort, atelectasis, and pneumonia.To overcome the blockage, the gut intensifies contractions, causing colicky abdominal pain, nausea, and vomiting, which reduces fluid and food intake and...
Sleep Apnea
Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
The condition is more prevalent among...
Acute Respiratory Failure-IV
Respiratory failure can manifest suddenly or gradually, characterized by a rapid decline in PaO2 and a rapid rise in PaCO2. This situation indicates a severe respiratory problem that may quickly become a life-threatening emergency. One of the early signs of hypoxemic Acute Respiratory Failure (ARF) is a change in mental status due to the brain's sensitivity to oxygen levels and changes in acid-base balance. Symptoms such as restlessness, confusion, and agitation suggest inadequate oxygen...

