Myocardial collagen network in dilated cardiomyopathy. Morphometry and scanning electron microscopy study

Although some form of myocyte damage is probably the main abnormality responsible for heart failure in dilated cardiomyopathy, abnormalities of the supporting interstitial collagen meshwork also occur. To see if abnormal collagen could be detected in cardiomyopathic hearts, which did not have interstitial fibrosis by routine light microscopy, we examined interstitial collagen using scanning electron microscopy and a novel digestion technique. Cardiomyopathetic collagen fibrils were significantly thicker and more densely packed than normal. We conclude that an ultrastructural collagen abnormality occurs early in dilated cardiomyopathy, this abnormality may contribute to the pathophysiology of this disease.