High precision quantitative angiography

Statistical considerations on the precision in the determination of blood vessel dimensions from digitized cine angiographic images are described. The resolution requirements related to "point measurements" and segmental diameter curve evaluations are discussed. The error associated with inaccurate determination of the vessel's centerline is analyzed. The concepts have been implemented on a high-speed image analyzing system, which measures blood vessel diameters with advanced automation. The performance of the system was evaluated with blood vessel phantoms, ranging in diameter from 0.88 to 6.26 mm. For these phantoms the minimum measurable change in vessel dimension over 20-pixel (-1.1 mm) long segments ranged from 3.4 to 0.2 percent, respectively.