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Working with Human Tissues for Translational Cancer Research
07:48

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Human experimentation and medical technology.

A L Caplan1

  • 1Minnesota Univ., Minneapolis, MN.

IEEE Engineering in Medicine and Biology Magazine : the Quarterly Magazine of the Engineering in Medicine & Biology Society
|January 1, 1988
PubMed
Summary
This summary is machine-generated.

Societal protections for human research subjects, including government regulation, informed consent, institutional review, and legal recourse, are reviewed. Defining the scope of research is also discussed.

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Area of Science:

  • Medical Ethics
  • Public Health Policy
  • Legal Studies

Background:

  • Human subjects research necessitates robust ethical oversight to prevent exploitation.
  • Societal norms and legal frameworks have evolved to protect participants.
  • Distinguishing between clinical practice and research is crucial for ethical conduct.

Purpose of the Study:

  • To examine the multifaceted protections implemented for human research subjects.
  • To discuss the definition and boundaries of human subjects research.
  • To analyze the effectiveness of current protective measures.

Main Methods:

  • Literature review of ethical guidelines and legal precedents.
  • Analysis of governmental regulations and institutional review board (IRB) functions.
  • Discussion of case law pertaining to malpractice suits in research settings.

Main Results:

  • Identified key protective mechanisms: government regulation, informed consent, local institutional review, and legal actions (malpractice).
  • Highlighted the ongoing challenge in clearly defining what constitutes human subjects research.
  • Emphasized the interconnectedness of regulatory, ethical, and legal safeguards.

Conclusions:

  • Existing protections for human research subjects are diverse and essential.
  • Clearer definitions of research are needed to ensure appropriate oversight.
  • A comprehensive approach integrating multiple protective layers is vital for ethical research conduct.