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Updated: Jul 7, 2026

Simultaneous Brightfield, Fluorescence, and Optical Coherence Tomographic Imaging of Contracting Cardiac Trabeculae Ex Vivo
Published on: October 2, 2021
Chrono-coherent imaging for medicine
K G Spears1, J Serafin, H Bjelkhagen
1Dept. of Chem., Northwestern Univ., Evanston, IL.
Abstract:
Imaging inside the body with optical wavelengths encounters problems due to light scattering of tissues and other optical distortions. A description is given of chrono-coherent imaging (CCI), a new method for imaging with visible and near-infrared light that uses coherent image formation and subpicosecond timing to remove the time-delayed scattered light. With CCI it is possible to form images in the presence of the overwhelming amount of scattered light that blocks conventional image formation. The coherent image formation process allows the use of long-duration, high-total-energy, and modest-peak-power pulses to overcome scattering losses. CCI is an extension of light-in-flight holography, which combines the properties of short-duration pulses and hologaphy for various measurements of objects and optical wavefronts.
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