Finite amplitude distortion-based inhomogeneous pulse echo ultrasonic imaging

Ultrasonic pulse echo imaging in inhomogeneous media suffers from significant lateral and contrast resolution losses due to the defocusing effects of the inhomogeneities. The losses in lateral and contrast resolution are associated with increases in the width of the mainbeam and increases in sidelobe levels, respectively. These two forms of resolution loss represent significant hurdles to improving the clinical utility of biomedical ultrasonic imaging. A number of research efforts are currently under way to investigate the defocusing effects of tissue and to consider corrective measures. All of these efforts assume linear propagation, and base the image-formation process on the reception of the transmitted pulse. A novel pulse echo imaging scheme in which the image is formed using the finite amplitude distortion components of the received pulse is considered here. Alternatively, this could be described as image formation using the nonlinearly-generated higher harmonics. In homogeneous beam propagations, it has been established that the sidelobes of nonlinearly-generated higher harmonics are much lower than their linear counterparts. Computations considered here suggest that this relationship also holds for the case of propagations through abdominal wall and breast wall tissue. These computations also suggest that the lateral resolution limits imposed by abdominal wall and breast wall tissue are slightly smaller for nonlinearly-generated second harmonics than for their linear counterparts. The resulting potential of these higher harmonics to improve image resolution is investigated.