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[Genomic approaches to bone and joint diseases. Current status of human disease genomics in rheumatoid arthritis]
Kenichi Shimane1, Kazuhiko Yamamoto, Yuta Kochi
1Institute of Physical and Chemical Research (RIKEN), SNP Research Center, Laboratory for Rheumatic Diseases/the University of Tokyo, Graduate School of Medicine, Department of Allergy and Rheumatology.
Abstract:
Rheumatoid arthritis (RA) is an autoimmune/inflammatory disorder which causes progression of polyarticular destruction. RA is a multifactorial disorder, in which genetic and environmental factors contribute to the onset of diseases. Linkage analyses and case-control association studies in RA have identified several susceptible genes including genetic variation in human leukocyte antigen region. Here, we review major genes susceptible to RA, and discuss effects of these genes on production of anti-cyclic citrullinated peptides antibody.
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