[Genomic approaches to bone and joint diseases. A genome-wide approach for analysis of polygenic diseases]

Genomic studies for human diseases has evolved into the genome-wide association studies (GWAS), from RFLP, VNTR, microsatellite marker. In GWAS approach, it has become possible to carry out genome wide surveys by genotyping large numbers of tagSNPs. In this literature, we outline a strategy of GWAS approach for the diseases, including marker selection, sample size, environmental biases and statistic methods that need to be taken into consideration, in order to optimize efficient study design of identifying disease susceptibility loci.