Related Experiment Video
Updated: Jul 7, 2026
10:33
Primed Mycobacterial Uveitis (PMU) as a Model for Post-Infectious Uveitis
Published on: December 17, 2021
Conjunctival involvement in chronic recurrent multifocal osteomyelitis
Zeynep Ozbek1, Balahan Makay, Erbil Unsal
1Department of Ophthalmology, Dokuz Eylul University, Izmir, Turkey. zeynep_ozbek@hotmail.com
Cornea
|February 5, 2008
Summary
Chronic recurrent multifocal osteomyelitis (CRMO) can affect the eyes, presenting as salmon-colored conjunctival lesions. Systemic steroid therapy effectively treated these ocular manifestations in a pediatric case.
Area of Science:
- Ophthalmology
- Rheumatology
- Pediatric Osteomyelitis
Background:
- Chronic recurrent multifocal osteomyelitis (CRMO) is a rare autoinflammatory bone disease predominantly affecting children.
- Ocular manifestations of CRMO are uncommon, with limited case reports in the literature.
Observation:
- A 10-year-old girl presented with chronic fatigue, leg pain, and recurrent conjunctivitis unresponsive to topical treatments.
- Examination revealed salmon-colored conjunctival lesions, and diagnostic workup confirmed CRMO with magnetic resonance imaging, bone scan, and biopsy.
Findings:
- Conjunctival biopsy showed chronic inflammatory infiltration with a prominent lymphocytic follicular pattern.
- The conjunctival lesions correlated with skeletal disease activity, worsening during relapses and improving with remission.
- Oral prednisolone therapy led to the resolution of conjunctival lesions and improvement of skeletal symptoms.
Implications:
- This case highlights conjunctival involvement as a potential extraskeletal manifestation of CRMO.
- Systemic corticosteroid therapy demonstrates efficacy in managing CRMO-associated conjunctival lesions.
- Early recognition and appropriate treatment of ocular findings may improve patient outcomes in CRMO.
Related Concept Videos
01:22Microbiome of the Eye
The human eye has a specialized microbiota that reflects its unique anatomical and immunological environment. This low-biomass microbial community predominantly colonizes the conjunctiva and eyelid margins, playing a vital role in ocular surface homeostasis and defense. Despite its proximity to the richly colonized facial skin, the ocular surface maintains a distinct microbial profile due to continuous mechanical and biochemical defense mechanisms.The conjunctival surface hosts fewer microbial...
01:27Cryptococcal Meningitis
Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
01:28Angle Closure Glaucoma: Treatment
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
01:27Open Angle Glaucoma: Treatment
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
01:25Glaucoma: Overview
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...