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Related Experiment Videos

Thalamic activation in a disc herniation model.

Helena Brisby1, Ingela Hammar

  • 1Department of Orthopaedics, Sahlgrenska University Hospital, Göteborg University, Göteborg, Sweden. helena.brisby@vgregion.se

Spine
|February 5, 2008
PubMed
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Nucleus pulposus (NP) applied to dorsal root ganglions (DRG) significantly increased thalamic responses, suggesting NP specifically affects pain pathways. This finding offers a new model for studying disc herniation and neuropathic pain.

Area of Science:

  • Neuroscience
  • Pain Research
  • Animal Models

Background:

  • Epidural nucleus pulposus (NP) with compression causes pain behaviors and spinal cord neuron activity.
  • Effects of NP on dorsal root ganglion (DRG) and thalamic neuronal activity remain uninvestigated.

Purpose of the Study:

  • To assess short-term effects of NP application on DRG on high-threshold afferent fiber evoked activation in the thalamus.

Main Methods:

  • A novel rodent model combining disc herniation and electrophysiologic recordings of thalamic evoked responses.
  • Recorded thalamic responses to sciatic nerve and L4 DRG stimulation before and during NP or adipose tissue (AT) application to L4 DRG.
  • Used AT as a control for mechanical effects of NP application.

Main Results:

Related Experiment Videos

  • NP application increased evoked thalamic responses to 138% +/- 10% after 20 minutes (P < 0.01).
  • AT application reduced evoked responses to 77% +/- 4% (P < 0.05).
  • Control animals showed stable thalamic activity for up to 40 minutes.

Conclusions:

  • NP application onto DRG increases afferent fiber evoked responses in the thalamus, suggesting NP-specific effects.
  • NP rapidly affects sensory pathways, likely via reversible changes in neuronal excitability.
  • This rodent model can study DRG injury-related thalamic activity and evaluate pain relief drugs.