A systematic library for comprehensive overexpression screens in Saccharomyces cerevisiae

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Mating-based Overexpression Library Screening in Yeast
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Mating-based Overexpression Library Screening in Yeast

Published on: July 6, 2018

Grace Marie Jones1, Jim Stalker, Sean Humphray

  • 1Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA.

Nature Methods
|February 5, 2008
PubMed

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Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...