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Related Experiment Video

Updated: May 8, 2026

Automated Measurement of Pulmonary Emphysema and Small Airway Remodeling in Cigarette Smoke-exposed Mice

Automated Measurement of Pulmonary Emphysema and Small Airway Remodeling in Cigarette Smoke-exposed Mice

Published on: January 16, 2015

Molecular pathogenesis of emphysema.

Laimute Taraseviciene-Stewart¹, Norbert F Voelkel

¹Pulmonary and Critical Care Medicine Division, University of Colorado Health Sciences Center, Denver, Colorado, USA.

The Journal of Clinical Investigation

|February 5, 2008

Summary

Emphysema, a progressive lung disease, results from damage to lung structure maintenance programs. Environmental factors like smoking and pollution trigger cellular damage, leading to airspace enlargement and disease.

Area of Science:

Pulmonary Medicine
Cellular Biology
Pathology

Background:

Emphysema is a chronic, obstructive, and progressive lung disease.
Cigarette smoking and air pollution are primary causes in humans and rodents.
The disease involves the destruction of lung tissue, specifically alveolar septal cells.

Purpose of the Study:

To review the concept of lung structure maintenance programs.
To explore inflammatory and noninflammatory mechanisms in emphysema pathogenesis.
To examine the role of immune systems in disease development.

Main Methods:

Review of scientific literature on emphysema.
Examination of genetically altered animal models.
Analysis of exposure models of the disease.

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Main Results:

Proteases and oxidants disrupt lung structure maintenance.
Loss of alveolar septal cells and airspace enlargement are key features.
Apoptosis, cellular senescence, and failed repair contribute to alveolar destruction.

Conclusions:

Emphysema results from a complex interplay of mechanical forces and cellular/molecular events.
Understanding these mechanisms is crucial for developing new therapeutic strategies.
Recent advances support a comprehensive model of emphysema pathogenesis.