Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Target Cell Response to Hormones01:22

Target Cell Response to Hormones

Hormones intricately bind to receptors on the surface or within target cells, initiating a cascade of cellular responses.
Notably, the cellular response can be regulated by altering the number of receptors expressed in the cell. For example, prolonged exposure to elevated hormone levels results in a gradual decline or down-regulation in the number of receptors for that specific hormone on the cell surface. Conversely, in response to low hormone levels, cells may use up-regulation, producing an...
Transducer Mechanism: G Protein–Coupled Receptors01:30

Transducer Mechanism: G Protein–Coupled Receptors

G Protein–Coupled Receptors (GPCRs) are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to various stimuli. GPCRs regulate critical physiological pathways and are excellent drug targets for treating diseases such as diabetes, cancer, obesity, depression, or Alzheimer's. Nearly 35% of approved drugs implement their therapeutic effects by selectively interacting with specific GPCRs.
GPCRs are also called heptahelical, 7TM, or...
Intracellular Hormone Receptors01:08

Intracellular Hormone Receptors

Lipid-soluble hormones diffuse across the plasma and nuclear membrane of target cells to bind to their specific intracellular receptors. These receptors act as transcription factors that regulate gene expression and protein synthesis in the target cell
Folliculogenesis01:20

Folliculogenesis

Folliculogenesis is the development of ovarian follicles, the specialized structures within the ovarian cortex where oogenesis, or egg development, occurs. This process is essential for female reproductive health and begins during fetal development when primordial follicles are formed. Each primordial follicle comprises a primary oocyte in the center, surrounded by a single layer of squamous pre-granulosa cells. These follicles remain dormant in late prophase I of meiosis until triggered by...
Signal Transduction: Overview01:26

Signal Transduction: Overview

Cells respond to many types of information, often through receptor proteins positioned on the membrane. They respond to chemical signals, such as hormones, neurotransmitters, and other signaling molecules, initiating a series of molecular reactions to produce an appropriate response. This is called signal transduction. Cells also coordinate different responses elicited by the same signaling molecule via mediators, allowing molecular cross-talk.
Typically, signal transduction involves three...
Receptor Downregulation in MVBs01:15

Receptor Downregulation in MVBs

Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
The EGFR can initiate signaling pathways that  lead to cell proliferation, migration, and differentiation. Overexpression of EGFR  stimulates cells to proliferate. Excessive  EGFR activation may...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pharmacological rescue of follicle-stimulating hormone receptor mutants. In vitro and in silico studies.

Endocrinology·2026
Same author

The implementation of small molecule agonists and antagonists to elucidate gonadotropin receptor structure, function and physiology.

Molecular and cellular endocrinology·2026
Same author

Editorial.

Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion·2025
Same author

Breast cancer and health inequalities: Another never ending story?

Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion·2025
Same author

Can Biomarkers Predict Kidney Function Recovery and Mortality in Patients with Critical COVID-19 and Acute Kidney Injury?

Diagnostics (Basel, Switzerland)·2025
Same author

Comment on "Atlas of Fshr Expression From Novel Reporter Mice".

Endocrinology·2025

Related Experiment Video

Updated: Jul 7, 2026

Exploring Independent Effects of Follicle-Stimulating Hormone In Vivo in a Mouse Model
05:32

Exploring Independent Effects of Follicle-Stimulating Hormone In Vivo in a Mouse Model

Published on: August 11, 2023

Multiple facets of follicle-stimulating hormone receptor function.

Alfredo Ulloa-Aguirre1, Teresa Zariñán, Ana Ma Pasapera

  • 1Research Unit in Reproductive Medicine, Hospital de Ginecobstetricia "Luis Castelazo Ayala", Instituto Mexicano del Seguro Social, Apartado Postal 99-065, Unidad Independencia, C.P. 10101 Mexico, D.F., Mexico. aulloaa@servidor.unam.mx

Endocrine
|February 5, 2008
PubMed
Summary

Follicle-stimulating hormone (FSH) is crucial for reproduction. Its receptor (FSHR) signaling involves intracellular domains that regulate reproductive functions.

More Related Videos

Gene Expression Analyses in Human Follicles
09:09

Gene Expression Analyses in Human Follicles

Published on: February 17, 2023

Related Experiment Videos

Last Updated: Jul 7, 2026

Exploring Independent Effects of Follicle-Stimulating Hormone In Vivo in a Mouse Model
05:32

Exploring Independent Effects of Follicle-Stimulating Hormone In Vivo in a Mouse Model

Published on: August 11, 2023

Gene Expression Analyses in Human Follicles
09:09

Gene Expression Analyses in Human Follicles

Published on: February 17, 2023

Area of Science:

  • Endocrinology
  • Molecular Biology
  • Reproductive Biology

Background:

  • Follicle-stimulating hormone (FSH) is a key pituitary hormone regulating reproduction.
  • The FSH receptor (FSHR) is a G protein-coupled receptor (GPCR) mediating FSH actions.
  • FSHR signaling impacts gonadal functions through various cellular cascades.

Purpose of the Study:

  • To review recent findings on FSH-activated signaling pathways.
  • To highlight the role of FSHR intracytoplasmic domains in signal transduction.
  • To elucidate the interaction of FSHR with cellular proteins involved in reproductive functions.

Main Methods:

  • Literature review of recent research on FSH and FSHR signaling.
  • Analysis of signaling cascades initiated by FSH binding to FSHR.
  • Examination of the function of FSHR intracytoplasmic domains.

Main Results:

  • FSHR activation triggers signaling cascades, notably the cAMP pathway.
  • Intracytoplasmic domains of FSHR are critical for signal transduction and termination.
  • These domains mediate interactions with membrane and cytosolic proteins.

Conclusions:

  • The FSH-FSHR system is central to reproductive regulation.
  • Understanding FSHR signaling, particularly its intracytoplasmic domains, is vital for reproductive biology.
  • Further research into these interactions can reveal new therapeutic targets.