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Updated: Jul 7, 2026

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
Published on: July 30, 2017
Palladium-catalyzed intramolecular chloroamination of alkenes
Forrest E Michael1, Paul A Sibbald, Brian M Cochran
1Department of Chemistry, University of Washington, Box 351700, Seattle, Washington 98195-1700, USA. michael@chem.washington.edu
Abstract:
A mild and facile Pd-catalyzed intramolecular chloroamination of unactivated alkenes has been described. This reaction takes place at room temperature and is tolerant of synthetically useful acid-sensitive functional groups. Generally high exo-selectivities are observed in the formation of a variety of 5- and 6-membered rings. This system is unique in its ability to tolerate multidentate ligands on palladium, which opens up the possibility of controlling the absolute sense of induction using a chiral ligand.
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